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This is one of the few activities I have found that can demonstrate natural selection. It does take a bit to set up with the cards (I keep mine from the previous years) and some careful explanation, but once it gets going, it is great to watch. Great at demonstrating natural selection, genetic variation, and environmental conditions. Students can also modify the rules and set up their own experiment.
If you like this activity, you can follow these links to other lessons and activities in my evolution unit.