This two-page worksheet guides students to apply their knowlege of basic biochemistry (e.g. structure and function of phospholipids, hydrophilic vs. hydrophobic properties, etc.) to gain a solid understanding of lipoproteins. The two main lipoproteins, HDL and LDL (i.e. good and bad cholesterol), are compared and contrasted in terms of both structure and function and then related to health concerns. Good and bad cholesterol are frequently mentioned in health-related news, but are rarely understood by the general public. This gives students the opportunity to understand the science underlying a popular topic.