In this activity, students use "unknown" sequences to search GenBank with a search tool called "blastn." The BLAST family of programs are very common tools in biological research and biotechnology. After doing the search, students answer questions about their results.
Links to the data set and an on-line tutorial can be found here at BLAST for beginners.
I recently updated the answer key and you can get it here. There's also a Teachers Guide Ebook that walks through the answers for each sequence and explains the results. You can find our teachers guide in the iTunes Book store or get the PDF version here!