A complete NGSS 5E lesson plan focusing on HS-LS1-2 and HS-LS1-4 that has students develop and revise a model for abnormal vs. normal cell division and function throughout the lesson. The lesson spans 2-3 weeks and includes embedded videos and Google resources. These resources include guiding/driving questions, phenomena videos, phenomenon reflection and KWL, Exploring Normal vs. Abnormal Cell Division activity, cell specialization and systems lab, Inside Cancer research, a chemotherapy lab, chemotherapy extension activities, and guideline/rubric for the final modeling project. Links to all resources are embedded and available as "View Only" Google documents. Simply "Make a Copy" to edit your own version. The lesson is targeted at biology students, but could easily be adapted for other life science subjects.