America Before Columbus (National Geographic, 2009) is a great program with an unfortunate name because it is really about the Colombian Exchange. It is also available on Youtube.
Intended for grades 6-12. World History or American History.
This handout spans the entire program and touches on the key factors, using short answer, fill in the blank and multiple choice.
I never watch a program in my class (7th Grade) without a handout.
Answer key included.