Each group is given a long paper strip of DNA, a 3-page story of the missing necklace and directions on how to fingerprint and sequence their DNA. Scissors act as the restriction enzyme, cutting the DNA between every CCGG into varied length segments. As the segments are pasted into the corresponding rows on the sequencing board (imitating gel electrophoresis), the DNA fingerprint of each suspect will emerge. So, who stole the necklace? Be a crime stopper!
With a focus on literacy and collaboration, this activity teaches students about the importance of enzymes, DNA sequencing, fingerprinting, mutations that can happen if we smoke and even what it means to be a twin.
Zip file includes:
Original "Who stole the necklace?" story
Directions to solve the crime
Teacher set up/lesson plan
DNA pasting chart
Follow up questions
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