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DNA and Chromosomes Activity Build a Boy or Girl Karyotype NGSS MS-LS3-1

Grade Levels
6th - 8th
Formats Included
  • PDF
4 pages
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Highly engaging genetics karyotyping activity! Students are given a set of chromosomes that may be from a male or a female and build a karyotype to find out! Half of the kids will get boys and half the kids will get girls, but it will be a surprise.

In this activity, students will:

  • Read clear step-by-step instructions
  • Cut out the chromosomes and match up the homologous pairs
  • Create a karyotype by pasting the matching chromosomes to their baby
  • Determine the gender of the baby by examining the karyotype
  • Answer 10 follow-up analysis questions

NO prerequisite knowledge of alleles or dominant/recessive is required for this activity. This activity focuses exclusively on chromosome numbers and building a karyotype.

NGSS Standard: MS-LS3-1

NGSS Science & Engineering Practice: Developing and using models

Teacher Notes:

Find more DNA & Chromosome resources in the DNA/Chromosomes Section of Our Store.

DNA/Chromosome Test (middle level)

DNA Fingerprinting Activity for Middle School

Simplified DNA Mutations Activity

Create a Paper Model of DNA

Chromosomes & Genetics Practice Sheet

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Total Pages
4 pages
Answer Key
Teaching Duration
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to see state-specific standards (only available in the US).
Develop and use a model to describe why asexual reproduction results in offspring with identical genetic information and sexual reproduction results in offspring with genetic variation. Emphasis is on using models such as Punnett squares, diagrams, and simulations to describe the cause and effect relationship of gene transmission from parent(s) to offspring and resulting genetic variation.
Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism. Emphasis is on conceptual understanding that changes in genetic material may result in making different proteins. Assessment does not include specific changes at the molecular level, mechanisms for protein synthesis, or specific types of mutations.


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