Introducing literacy into the content areas is a best practice in today's high school science classroom. This reading guide is designed to be used by students reading E=mc2, A Biography of the World's Most Famous Equation by David Bodanis. There are over 150 questions written by me, a high school physics teacher, designed to help my physics students understand the author's point of view as we read this book in class next year. Questions are chronological and in short answer format. Answer key is included.