This zip file contains many different activities (41 pages of student handouts and 2 PowerPoints with a total of 95 slides) which can be used to compose a unit for AP Biology or advanced Biology students involving major topics concerning enzymes. Topics in this unit enzymes and reaction rate, enzyme structure, substrates, active sites, lock and key versus the induced fit enzyme model, factors including enzyme activity including pH, temperature, salts, competitive and noncompetive inhibitors, allosteric effects, zymogens and feedback inhibition.
While these lessons were originally designed for my AP Biology curriculum, they can be adapted to any advanced level Biology program.
I have included online textbook and a video link with the worksheets in this learning packet. These links work currently as of 9/6/16. I can not guarantee that these links will not change or "disappear". Having said that, these worksheets work well with the provided curriculum materials and any AP Biology Collegeboard approved textbook.
This lesson packet contains a listing of the learning goals, common core learning standards, NGSS learning standards and the AP Biology performance indicators addressed in these materials. These are included in the packet and at the end of the description of this lesson.
The components of this lesson package can easily be displayed to students using and LCD projector and may be readily modified into formats facilitating smartboard technology. Most documents are included in both word doc or docx as well as pdf format to allow editing for specific teacher needs. The learning guides/assignments contain links to online resources to support student learning.
Answer keys are included for all items including some suggested answers for the three lab activities (as the answers and data obtained by students can exhibit a good deal of variation).
All documents are included in word and pdf format The specific contents of the learning package includes the page count for the student documents as answer key page counts are not included. The specific contents listed below:
-- Enzyme Learning Standards and Objectives (2 pages)
-- Brief Review of Kinetics and Potential Energy Diagrams PowerPoint (28 slides)
-- Completion Notes to accompany the Brief Review of Kinetics and Potential Energy Diagrams PowerPoint (3 pages)
-- Enzyme PowerPoint (67 slides)
-- Completion Notes to accompany the Enzyme PowerPoint (9 pages)
-- Enzyme Exam with key (50 questions) (9 pages)
-- Enzyme Worksheet # 1 with key (8 questions) (2 pages)
-- Enzyme Worksheet # 2 with key (5 multi-part question with graph) (3 pages)
-- Factors Influencing Reaction Rates Lab (6 pages)
-- Enzyme Reaction Rate Lab with key (3 pages)
-- Instructions and How to do video for the Enzyme Catalysis Reaction Rate Lab (2 pages)
-- Paperase Lab with Key (4 pages)
Enzyme Learning Objectives ETS
BIG IDEA #4: BIOLOGICAL SYSTEMS INTERACT, AND THESE SYSTEMS AND THEIR INTERACTIONS POSSESS COMPLEX PROPERTIES
Enduring understanding 4.A: Interactions within biological systems lead to complex properties.
Essential knowledge 4.A.1: The subcomponents of biological molecules and their sequence determine the properties of that molecule.
LO 4.1 The student is able to explain the connection between the sequence and the subcomponents of a biological polymer and its properties.
LO 4.2 The student is able to refine representations and models to explain how the subcomponents of a biological polymer and their sequence determine the properties of that polymer.
LO 4.3 The student is able to use models to predict and justify that changes in the subcomponents of a biological polymer affect the functionality of the molecule.
Enduring understanding 4.B: Competition and cooperation are important aspects of biological systems.
Essential knowledge 4.B.1: Interactions between molecules affect their structure and function.
LO 4.17 The student is able to analyze data to identify how molecular interactions affect structure and function.
Enzyme Student Learning Goals
Upon the completion of this unit the student will be able to:
1. describe the influence of enzymes on chemical reactions and represent this influence on a potential energy diagram.
2. describe the basic structure of an enzyme.
3. define the terms substrate and active site.
4. describe the role of coenzymes and cofactors in relation to the structure and function of enzymes.
5. compare the lock and key and induced fit hypotheses of enzyme function.
6. discuss how and why changes in temperature, pH, and ion concentration influence enzyme activity.
7. define the term denaturization.
8. recognize the effects when a fixed amount of enzyme is placed with an excess of substrate and explain why these effects occur.
9. recognize the effects when a fixed amount of substrate is placed with an excess of enzyme and explain why these effects occur.
10. explain how enzyme activity can be regulated by competitive and noncompetitive inhibition.
11. define the term zymogen and discuss an example of this.
12. define the term allosteric interaction and explain how these can be used to regulate metabolic pathways.
HS-LS1-6. Construct and revise an explanation based on evidence for how carbon, hydrogen, and oxygen from sugar molecules may combine with other elements to form amino acids and/or other large carbon-based molecules.
Common Core State Standards Connections:
RST.11-12.1 Cite specific textual evidence to support analysis of science and technical texts, attending to important distinctions the author makes and to any gaps or inconsistencies in the account.
WHST.9-12.2 Write informative/explanatory texts, including the narration of historical events, scientific procedures/ experiments, or technical processes.
WHST.9-12.5 Develop and strengthen writing as needed by planning, revising, editing, rewriting, or trying a new approach, focusing on addressing what is most significant for a specific purpose and audience.
WHST.9-12.9 Draw evidence from informational texts to support analysis, reflection, and research.
MP.4 Model with mathematics.