This full-page crossword puzzle is about the heart and the circulatory system. I assign it in my Human Anatomy and Physiology Course in the aforementioned unit. The clues question students on the following terms: mitral valve, venules, myocardium, atrioventricular, common iliac arteries, portal vein, valves, pericardium, arterioles, capillaries, septum, systole, great saphenous vein, sinoatrial node, diastole, pulmonic valve, sinoatrial valve, systemic, veins, angina pectoris, pulmonary veins, and myocardial infarction. This document is editable. The answer key is included.