Students are placed in one of 6 groups and given different topics regarding the immune system. Topics range from understanding how the immune system distinguishes self from non self, comparing autoimmune diseases, allergies, Rh factors, organ transplantation. Other topics are understanding how vaccines work with the immune system and the differences between active and passive immunity.
This activity could be modified to be a shorter version to take one class, or carried out as a large research project. It would also work great as a jigsaw.