Students will be introduced to the idea of Natural Selection and basic ecology. Understanding the intricate relationship between genes, the environment, and change that could occur over time is the focus of this article. Investigative questions about antibiotic resistance, depleting cheetah populations, and a brief history of Darwin's observations allow students to apply the idea of natural selection to current populations. Intended to cover the Tennessee Science Standards 8. LS4.3 and 8.LS4.4, this article can also be used for NGSS standards or any other academic standards that are similar.