This is an introductory inquiry activity into the structure of biological macromolecules (carbohydrates, lipids, proteins, and nucleic acids), like you have never seen before. It takes a difficult topic to teach and turns it into an engaging activity, in which students discover far more than they realize. It offers practice in examining and comparing molecular formulas, full display structures, and skeletal structures for organic molecules in order to determine a system to categorize the given molecules. This multi-day activity will be a challenge for all students, which requires minimal prerequisite knowledge. By the end of this activity, students will have discovered functional groups and structural similarities of carbohydrates, lipids, and amino acids. They will also have experience with the basic components of nucleotides. The downloadable document contains the numbered molecules for use in the activity, lesson instructions for the student and instructor, prerequisite knowledge required, connection points for summarizing and leading in to your next instruction on macromolecules, student worksheet, and answer key.