I created this activity as a part of a unit on biotechnology and DNA. Students can do this activity on their own, though it would probably work better as a guided group activity. Each section has a description and an activity for students to complete such as labeling or answering questions.
The first section starts with an explanation on how DNA from a sample is cut into fragments with restriction enzymes. Students identify recognition sites of the Smal enzyme and determine how many fragments would be made if the DNA sequence were cut with it. They are also given information about how small samples of DNA from blood can be copied and amplified with PCR.
The procedure of gel electrophoresis is described and students analyze a sample showing fragment lengths. This helps students realize that different fragments would be cut if different enzymes are used.
Finally, students analyze crime scene DNA fingerprints and a paternity DNA test. Matching bands are colored and identified to solve the mysteries.
This worksheet is available for free at biologycorner.com
Download includes the answer key, student version as a word document, and a link to the Google Doc file of the student version.