This worksheet accompanies the Molecule World DNA Binding Lab iPad app from Digital World Biology (http://digitalworldbiology.com). MW DNA Binding Lab allows students to explore DNA molecules in three dimensions, uncover information about DNA structure, and investigate the way that other molecules bind to DNA. Some molecules, like anticancer drugs, bind to DNA and prevent it from being copied or transcribed. Some molecules, like restriction enzymes cut DNA, some copy DNA, some make RNA, others repair DNA, and others, like transcription factors regulate these processes. Students explore several different types of interactions between other molecules and DNA and identify the major structural features in the DNA that are recognized by the drugs or proteins.