Muscular System Activities - Muscle Fatigue Lab Activity

Rated 4.68 out of 5, based on 53 reviews
53 Ratings
Suburban Science
Grade Levels
9th - 12th, Homeschool
Formats Included
  • PDF
4 pages
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Suburban Science
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  1. Looking for anatomy resources to fit the laboratory portion of a high school Biology or Human Anatomy course? This Anatomy and Physiology bundle contains 34 thorough and engaging activities for hands-on learning! The labs and activities included in this bundle are designed to be easy to use and al
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This quick NO-PREP lab activity is the perfect addition to your muscular system unit! Students learn about the molecules involved in muscle fatigue, then demonstrate the process by purposely fatiguing various muscle groups. This is a favorite lab in any high school Biology or Anatomy classroom!

Teacher instructions and student pages are provided.

PLEASE NOTE: This resource is part of my Muscular System Unit and my Human Body Systems MEGA-Bundle (PowerPoints, Notes, Labs, Diagrams).

Many students come into high school with misinformation on muscle fatigue and the role of lactic acid during exercise. The background information in this lab is based on the most recent data regarding muscle fatigue and the molecules involved.

Topics include: aerobic respiration, anaerobic respiration, lactic acid, lactate, lactate threshold, ATP, delayed onset muscle soreness (DOMS)

Included in this resource:

-1 teacher instruction page

-1 student page with background information on muscle fatigue (print & digital versions included)

-1 lab page for recording data and drawing conclusions (print & digital versions included)

-Answer key

For close-up images of the pages included in this bundle, please click on the "PREVIEW" button.

This activity addresses NGSS HS-LS1-2.


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Total Pages
4 pages
Answer Key
Teaching Duration
40 minutes
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to see state-specific standards (only available in the US).
Use a model to illustrate that cellular respiration is a chemical process whereby the bonds of food molecules and oxygen molecules are broken and the bonds in new compounds are formed, resulting in a net transfer of energy. Emphasis is on the conceptual understanding of the inputs and outputs of the process of cellular respiration. Assessment should not include identification of the steps or specific processes involved in cellular respiration.
Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms. Emphasis is on functions at the organism system level such as nutrient uptake, water delivery, and organism movement in response to neural stimuli. An example of an interacting system could be an artery depending on the proper function of elastic tissue and smooth muscle to regulate and deliver the proper amount of blood within the circulatory system. Assessment does not include interactions and functions at the molecular or chemical reaction level.


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