This activity set includes two one-page crossword puzzles about the muscular system for a Human Anatomy and Physiology course. There is a total of twenty-three clues that need to be solved for completion. Vocabulary terms and/or topics covered among the clues include but are not limited to: sarcomere, diaphragm, prime mover, smooth muscle, latissimus dorsi, hypertonia, trapezius, striated, actin, spasm, orbicularis oris, location, atrophy, neuromuscular junction, zygomaticus, tendon, quadriceps femoris, shin splints, tendon, somatic nerve, triceps brachii myalgia, aerobic metabolism, and somatic nerve. The clues collectively probe students’ understanding of muscle anatomy, physiology, and classification. Two one-page answer keys are included.