When I teach Macbeth, I center the entire unit around the Human Psyche. We discuss various mental disorders and discuss the ongoing argument of nature vs. nurture. I usually have my students complete this assignment as a summative assessment at the end of the play. It analyzes the characters in Macbeth through the lens of various psychological disorders. Links are embedded to other articles and documents as well. This could then lead into an essay on nature vs. nurture.