This anacrostic puzzle is an excellent followup activity to reading Steinbeck's "Of Mice and Men." It captures the tragic essence of the novel as well as the local color Steinbeck employed.
Anacrostic puzzles highlight a long quotation -- this one from "Of Mice and Men" -- as well as terms and concepts germane to the puzzle's theme. Students will quickly learn how they work and, if my experience of distributing them to students for twenty years is an indication, will become big fans of them ... big, quiet fans. Once you pass them out, students, working solo or in groups, silence will descend on the classroom as they race to be the first one(s) done.
Of course, if they don't finish in class (and many won't) they're an excellent homework assignment. They're easy to grade with a quick scan for completion (I gave 10 points) and can be used as extra credit work. The best thing about anacrostics -- and the reason they were invented by English teacher Elizabeth Kingsley in New York City in 1934 -- is that they are a very effective way of getting students to engage with the great quotes of literature.