This game has students play memory (or just matching the prefix/root word) to its definition. I have included directions for playing the game for students, game assembly instructions for teachers, and a reminder of what prefixes mean for students. The game uses the prefixes: un-, dis-, im-, il-, in-, re-, mis-, and pre-. I have also included blank card pages which you can use to make more cards or have students create their own matches. This game is great for literacy centers.