This EDITABLE, hands-on activity asks students to explore the chemical properties of amino acids and how they determine the shape of a protein. Students place amino acids (beads) on polypeptide chain (pipe cleaners or a wire). Each color bead represents an amino acid with a different property: hydrophobic, hydrophilic, positive and negative charges.
After answering analysis questions, students add a mutation. They change one amino acid and see how it affects the structure of their protein. Finally, students apply what they learned to a real world situation: sickle cell anemia.
HS-LS1-1.Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins which carry out the essential functions of life through systems of specialized cells.
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