I used this activity with high school students taking a human disease course at an alternative high school. It could easily be used to enrich elementary science curriculum, with middle school life science students, or in a high school biology course.
The first 4 worksheets are easy guided practice through sex-linked (X-linked) disorders. They could easily be used as homework. The last two sheets illustrate hemophilia in the royal family and give students a chance to read an authentic pedigree chart. Students will directly see the connection between punnett square predictions and outcomes in a pedigree.
All sheets come with a complete answer key.