TED's Disease challenges students to investigate a specific genetic disorder then use their findings to contribute to the global knowledge base via the creation of a TED ED learning module. This project was initially created for an AP Biology class, but could easily be adjusted for any number of courses.
A couple examples of my students' work:
Huntington's Disease - http://ed.ted.com/on/cIDw2gon#watch
Achromatopsia - http://ed.ted.com/on/uPXFSwfM#watch
-Student project document with the project introduction, all directions, and project requirements
-Customizable, 11-item rubric
Preview includes driving question and project introduction.