I love reading Tale of Despereaux with my students in guided reading. I downloaded "The Tale of Despereaux - Novel Study" by Marsha and I love it. I wanted to add something to the questions that really focus on vocabulary. I only have this completed so far for Book One. I will be creating a similar document for the last three "books".
Some chapters have new words that students will write the sentence and then infer the meanings of the word. Other chapters include questions about author's word choice for particular descriptions or phrases. I tried to make everything text-based so that students will need to refer to the text evidence in order to infer the meaning of words or answer the vocabulary questions.