This worksheet brings together the topics of mutation, genetics and evolution as it explains about the genetics of Sickle Cell Anemia and how carrying the sickle cell trait can protect carriers from malaria. I give the basic information to the students with a worksheet that shows the basics drawn in. Students have to fill in empty places by reading the information on the first page. You can have students write an essay when they are done about why having the sickle cell trait largely protects carriers from getting sick with malaria. This satisfies the Common Core idea.