A complete NGSS 5E lesson plan focusing on HS-LS1-2 and HS-LS1-3 that has students model and investigate factors that influence blood flow and blood pressure. The lesson spans 2-3 weeks and includes embedded videos and Google resources. These resources include guiding/driving questions, phenomena videos, pulse present vs. absent modeling guide, discussion questions, exploring pulse and blood pressure activity, cardiovascular system station activity, factors affecting blood flow research, heart valve replacement engineering lab, and guideline/rubric for a blood flow investigation. Links to all resources are embedded and available as "View Only" Google documents. Simply "Make a Copy" to edit your own version. The lesson is targeted at biology students, but could easily be adapted for other life science subjects.