DNA Mutations Lab Activity: Distance Learning

Grade Levels
9th - 10th
Resource Type
Formats Included
  • Zip
Student Handout (4 Pages)
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  1. This bundle includes four genetics lab activities: Build Your Own Candy DNA Lab, DNA Mutations Lab, Paper Plasmids: A Genetic Engineering Activity, and Simulated Gel Electrophoresis Lab : Who Robbed the Bank? Included as a free bonus file is my genetics study guide foldable activity. For more deta
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In this lab activity, students analyze the effects of several different types of mutations on a DNA sequence and the subsequent protein produced. To represent the randomness of DNA mutations, a dice is rolled to determine what type of mutation each student receives (substitution, insertion, or deletion of one nucleotide). Students will complete two trials of mutations (first they will mutate the fourth nucleotide, and then the sixth), and compare the outcomes of these trials to determine which one had a more detrimental effect on the amino acid sequence. A complete answer key of all possible mutation outcomes for each trial is included.

This activity is a great way for students to understand the impact of one single nucleotide change on a protein. All you need are some dice!

Distance Learning:

As this activity only requires a six-sided die (which many students have at home from many board games), this can be a great distance learning option! Students can type directly on the document and submit it virtually. If a student does not have a dice at home, instruct them to Google "virtual dice" and they can roll a virtual dice online!

If using Google Classroom, you are provided with a link to a Google Docs version of the lab activity!

This product pairs wonderfully with my guided notes on genetic mutations which can be found HERE! Purchase both resources together as a bundle HERE!

Included in the Zip File:

DNA Mutations Lab Student Handout (Word Doc)

Teacher Answer Key

PDF with link to Google Docs version of DNA Mutations Lab

Total Pages
Student Handout (4 Pages)
Answer Key
Teaching Duration
1 hour
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to see state-specific standards (only available in the US).
Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism. Emphasis is on conceptual understanding that changes in genetic material may result in making different proteins. Assessment does not include specific changes at the molecular level, mechanisms for protein synthesis, or specific types of mutations.
Make and defend a claim based on evidence that inheritable genetic variations may result from (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors. Emphasis is on using data to support arguments for the way variation occurs. Assessment does not include the phases of meiosis or the biochemical mechanism of specific steps in the process.


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