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Genetic Mutations & Variation Virtual Lab Worksheets | NGSS Inquiry Simulation
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What others say

"This was a great no-prep way to get away from traditional textbook/worksheet work. My students learned more from this than they did the actual lesson about mutations because it was more engaging!"
star
Autumn L.

Description

Help your students explore genetic mutations and variation with the Genetic Mutations and Variation Virtual Lab Activity with Guided Student Worksheets & Science Simulation! 

Designed to promote scientific inquiry, this no-prep interactive virtual lab activity allows students to explore genetic mutations and variation using an NGSS-aligned phenomena-based science simulation! The student worksheet guides students through the simulation to ensure comprehension and understanding, while also encouraging students to make predictions, observations, analyze data, and form conclusions. Check out the preview to see more!

Skills Students Will Practice:

⚗️ Test their Pre-existing Knowledge of Mutations

⚗️ Identify the difference between Point, Insertion, & Deletion Mutations

⚗️ Read about Genetic Mutations and how they can be Good & Bad

⚗️ Describe how Changes in DNA sequence influence Protein Formation

⭐ This Activity is Perfect for:

⚗️ Middle school and high school science lessons

⚗️ NGSS-aligned science instruction

⚗️ Virtual labs for blended, digital, or distance learning

⚗️ Sub plans, enrichment, or independent practice

NOTE: This activity links to a video clip and an Interactive from the Genetic Science Learning Center Website. Check it out below!

Video: Types of Mutations

Interactive: Mutations & Variation

Purchase includes the 3-page Student Worksheet (PDF), 3-page Teacher Answer Key (PDF), and 3-page Digital Student Worksheet (Google Slides) that is hyperlinked in the Teacher Answer Key.

Looking for more Genetics Virtual Labs? Shop these products

⚗️ Build a DNA Molecule Guided Virtual Science Lab Activity

⚗️ Three Types of RNA Guided Virtual Science Lab Activity

⚗️ Transcription & Translation Guided Virtual Science Lab Activity

⚗️ Inheritance of Traits Guided Virtual Science Lab Activity

⚗️ Gene Expression Guided Virtual Science Lab Activity

⚗️ Polymerase Chain Reaction Guided Virtual Science Lab Activity

❗Permission is granted to copy pages specifically for student or teacher use only by the original purchaser or licensee. The reproduction of this product for any other use is strictly prohibited. Copying this product in any part and placing it on the Internet (even on a personal website) is strictly prohibited and a violation of the Digital Millennium Copyright Act (DCMA).

_________________________________________________________________


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Report this resource to TPT
Reported resources will be reviewed by our team. Report this resource to let us know if this resource violates TPT's content guidelines.

Genetic Mutations & Variation Virtual Lab Worksheets | NGSS Inquiry Simulation

Building Brix of Science
428 Followers
$3.25

Highlights

Standards icon
Standards
Pages
9
Answer Key
Included
Teaching Duration
50 minutes

What others say

"This was a great no-prep way to get away from traditional textbook/worksheet work. My students learned more from this than they did the actual lesson about mutations because it was more engaging!"
star
Autumn L.

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Description

Help your students explore genetic mutations and variation with the Genetic Mutations and Variation Virtual Lab Activity with Guided Student Worksheets & Science Simulation! 

Designed to promote scientific inquiry, this no-prep interactive virtual lab activity allows students to explore genetic mutations and variation using an NGSS-aligned phenomena-based science simulation! The student worksheet guides students through the simulation to ensure comprehension and understanding, while also encouraging students to make predictions, observations, analyze data, and form conclusions. Check out the preview to see more!

Skills Students Will Practice:

⚗️ Test their Pre-existing Knowledge of Mutations

⚗️ Identify the difference between Point, Insertion, & Deletion Mutations

⚗️ Read about Genetic Mutations and how they can be Good & Bad

⚗️ Describe how Changes in DNA sequence influence Protein Formation

⭐ This Activity is Perfect for:

⚗️ Middle school and high school science lessons

⚗️ NGSS-aligned science instruction

⚗️ Virtual labs for blended, digital, or distance learning

⚗️ Sub plans, enrichment, or independent practice

NOTE: This activity links to a video clip and an Interactive from the Genetic Science Learning Center Website. Check it out below!

Video: Types of Mutations

Interactive: Mutations & Variation

Purchase includes the 3-page Student Worksheet (PDF), 3-page Teacher Answer Key (PDF), and 3-page Digital Student Worksheet (Google Slides) that is hyperlinked in the Teacher Answer Key.

Looking for more Genetics Virtual Labs? Shop these products

⚗️ Build a DNA Molecule Guided Virtual Science Lab Activity

⚗️ Three Types of RNA Guided Virtual Science Lab Activity

⚗️ Transcription & Translation Guided Virtual Science Lab Activity

⚗️ Inheritance of Traits Guided Virtual Science Lab Activity

⚗️ Gene Expression Guided Virtual Science Lab Activity

⚗️ Polymerase Chain Reaction Guided Virtual Science Lab Activity

❗Permission is granted to copy pages specifically for student or teacher use only by the original purchaser or licensee. The reproduction of this product for any other use is strictly prohibited. Copying this product in any part and placing it on the Internet (even on a personal website) is strictly prohibited and a violation of the Digital Millennium Copyright Act (DCMA).

_________________________________________________________________


⭐ BE THE FIRST TO LEARN ABOUT NEW SCIENCE RESOURCES! ⭐

Hit the Green Star at the top of the page to follow my store! This will allow you to receive notifications whenever I update current resources and add brand new items.

Report this resource to TPT
Reported resources will be reviewed by our team. Report this resource to let us know if this resource violates TPT's content guidelines.

Reviews

4.8
Rated 4.76 out of 5, based on 21 reviews
21
ratings
5
16
4
5
3
0
2
0
1
0
Mostly used with 7th and 8th grades
Reviews
2
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2
6th
7th
8th
9th
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12th
All verified TPT purchases
Great visualization
Rated 5 out of 5
May 27, 2026
Great visualization of the concepts to review for TCAP during state testing review.
Stephanie B.
165 reviews • Tennessee
Grades taught: 7th
Student populations: Emerging bilinguals
Excellent Sub plan
Rated 5 out of 5
February 24, 2026
Met expectations
Great value
Standards-aligned
I used this as a sub plan and it was fantastic! Easy for student to naivage and understand.
Lisa E.
178 reviews • Michigan
Grades taught: 6th, 7th, 8th
Great Resource
Rated 5 out of 5
February 16, 2026
This was a fun and engaging activity for my Biology students.
April T.
119 reviews • California
Grades taught: 9th, 10th, 11th, 12th
A great resource
Rated 5 out of 5
January 12, 2026
Met expectations
Great value
Standards-aligned
My students enjoyed this activity and it helped solidify their understanding
Sarah Vest
(TPT Seller)
168 reviews • Michigan
Grades taught: 8th
Student populations: Learning difficulties
Great Resource
Rated 5 out of 5
August 14, 2025
Loved using this in my middle school classroom. Thank you!
Staccy K.
2,604 reviews • Illinois
Rated 5 out of 5
May 27, 2025
This was a great no-prep way to get away from traditional textbook/worksheet work. My students learned more from this than they did the actual lesson about mutations because it was more engaging!
Autumn Litteken
(TPT Seller)
183 reviews
Grades taught: 11th
Rated 4 out of 5
May 13, 2025
I used this resource as additional information to enforce the standard and concept.
Julie C.
98 reviews
Grades taught: 7th
Rated 5 out of 5
April 12, 2025
Great resource that I used to supplement our curriculum.
Taylor W.
283 reviews
Grades taught: 8th

Questions & Answers

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Standards

to see state-specific standards (only available in the US).
NGSSHS-LS3-1
Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring. Assessment does not include the phases of meiosis or the biochemical mechanism of specific steps in the process.
NGSSMS-LS3-1
Develop and use a model to describe why structural changes to genes (mutations) located on chromosomes may affect proteins and may result in harmful, beneficial, or neutral effects to the structure and function of the organism. Emphasis is on conceptual understanding that changes in genetic material may result in making different proteins. Assessment does not include specific changes at the molecular level, mechanisms for protein synthesis, or specific types of mutations.
NGSSHS-LS3-2
Make and defend a claim based on evidence that inheritable genetic variations may result from (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors. Emphasis is on using data to support arguments for the way variation occurs. Assessment does not include the phases of meiosis or the biochemical mechanism of specific steps in the process.
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