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Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning
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What others say

"This was a great activity I used with freshman bio and as a review for my biotech elective. So engaging!! "
star
Alayna T.
"I didn't use this resource, but wanted to leave positive feedback. It really is a great resource for protein shape/ mutations. After I bought it, it was just too advanced for my 7th graders. It's awesome for high school curriculum though!"
star
Donna B.

Description

In Brief: First, students read about protein synthesis, gene mutations, and chromosomal mutations. Then, students practice transcribing and translating mutated genes, identifying the type of mutation that occurred. Then, students read about protein structure, and put it all together using normal/sickle hemoglobin as an example. By comparing the change in amino acid sequence, students determine the cause of sickle hemoglobin, and construct origami models of the normal/sickle hemoglobin. Finally, students sum up what they’ve learned in a conclusion section.

A. NEXT GENERATION SCIENCE STANDARDS HEREIN

DCI’s: LS1.A: Structure and Function

LS3.A: Inheritance of Traits

LS4.C: Adaptation

Cross Cutting Concepts: Cause and Effect, Systems and Systems, Structure and Function, Stability and Change

Scientific and Engineering Practices:

Analyzing and Interpreting Data

Developing and Using Models

Engaging in Arguments from Evidence

B. SUGGESTED USES

Here are some other products you might like:

Viruses and Bacteria Stations Lab: Six stations explore Structure, Function, Immunity, Vaccines

Protein Synthesis Bingo Game: Practice questions on the topic the fun way

Want a protein synthesis activity that is a bit simpler than this one? Get it here: Making a Monster Using Protein Synthesis

Cell Cycle Board Game: A fun, challenging way to learn the complexities of the cell cycle

Epic Dragon Project: Must students all time favorite multi-topic project on genomics, protein synthesis, meiosis, fertilization, and natural selection.

Prior Knowledge: No specific prior knowledge is required for this lab. Some very basic concepts in genetics are touched upon, but all the info that is needed to complete the activity is provided.

Implementing the Lesson:

Materials (per student):

1. One Packet

2. One sheet of Origami Templates for normal hemoglobin (provided)

3. One sheet of Origami Templates for sickle hemoglobin (provided)

4. Internet access to watch video instructions for folding the templates

5. Scissors (not provided)

6. Tape (not provided)

I usually print the hemoglobin templates on colored paper (normal hemoglobin on one color, and sickle hemoglobin on another. Also, I encourage students to connect several student’s sickle hemoglobin models together to form a larger “fiber”, which is what occurs inside the sickle red blood cell, leading to its half-moon shape.

This product comes as a word doc, and a PDF, so that you may edit it, if you choose.

This activity is designed to be student centered. With monitoring and guidance from a teacher, students can work through this activity, as-is.

My students have fun with this. If yours liked it, there are more like this at my TpT store:

http://www.teacherspayteachers.com/Store/Next-Gen-Sci-Guy

Terms of Use

• This packet is 1 classroom/teacher use only. Do not make copies or

email it to your colleagues. This was designed by me and is for your

personal (one user)use. You may

not share it or claim it as your own. You may not redistribute it.

If colleagues are interested in it, please send them the link to my store:

https://www.teacherspayteachers.com/Store/Next-Gen-Sci-Guy

• You are not permitted to use any part of this work to

create products for sharing or selling.

• You are permitted to share the cover image of the packet

on your website when referring to it in a post, as long as

you link back to my store.

All rights reserved by author.

Report this resource to TPT
Reported resources will be reviewed by our team. Report this resource to let us know if this resource violates TPT's content guidelines.

Protein Synthesis, Mutations & Modeling Hemoglobin Lab: NGSS - Distance Learning

Next Gen Sci Guy
956 Followers
$5.50

Highlights

Pages
12
Answer Key
Included
Teaching Duration
1 hour

What others say

"This was a great activity I used with freshman bio and as a review for my biotech elective. So engaging!! "
star
Alayna T.
"I didn't use this resource, but wanted to leave positive feedback. It really is a great resource for protein shape/ mutations. After I bought it, it was just too advanced for my 7th graders. It's awesome for high school curriculum though!"
star
Donna B.

Description

In Brief: First, students read about protein synthesis, gene mutations, and chromosomal mutations. Then, students practice transcribing and translating mutated genes, identifying the type of mutation that occurred. Then, students read about protein structure, and put it all together using normal/sickle hemoglobin as an example. By comparing the change in amino acid sequence, students determine the cause of sickle hemoglobin, and construct origami models of the normal/sickle hemoglobin. Finally, students sum up what they’ve learned in a conclusion section.

A. NEXT GENERATION SCIENCE STANDARDS HEREIN

DCI’s: LS1.A: Structure and Function

LS3.A: Inheritance of Traits

LS4.C: Adaptation

Cross Cutting Concepts: Cause and Effect, Systems and Systems, Structure and Function, Stability and Change

Scientific and Engineering Practices:

Analyzing and Interpreting Data

Developing and Using Models

Engaging in Arguments from Evidence

B. SUGGESTED USES

Here are some other products you might like:

Viruses and Bacteria Stations Lab: Six stations explore Structure, Function, Immunity, Vaccines

Protein Synthesis Bingo Game: Practice questions on the topic the fun way

Want a protein synthesis activity that is a bit simpler than this one? Get it here: Making a Monster Using Protein Synthesis

Cell Cycle Board Game: A fun, challenging way to learn the complexities of the cell cycle

Epic Dragon Project: Must students all time favorite multi-topic project on genomics, protein synthesis, meiosis, fertilization, and natural selection.

Prior Knowledge: No specific prior knowledge is required for this lab. Some very basic concepts in genetics are touched upon, but all the info that is needed to complete the activity is provided.

Implementing the Lesson:

Materials (per student):

1. One Packet

2. One sheet of Origami Templates for normal hemoglobin (provided)

3. One sheet of Origami Templates for sickle hemoglobin (provided)

4. Internet access to watch video instructions for folding the templates

5. Scissors (not provided)

6. Tape (not provided)

I usually print the hemoglobin templates on colored paper (normal hemoglobin on one color, and sickle hemoglobin on another. Also, I encourage students to connect several student’s sickle hemoglobin models together to form a larger “fiber”, which is what occurs inside the sickle red blood cell, leading to its half-moon shape.

This product comes as a word doc, and a PDF, so that you may edit it, if you choose.

This activity is designed to be student centered. With monitoring and guidance from a teacher, students can work through this activity, as-is.

My students have fun with this. If yours liked it, there are more like this at my TpT store:

http://www.teacherspayteachers.com/Store/Next-Gen-Sci-Guy

Terms of Use

• This packet is 1 classroom/teacher use only. Do not make copies or

email it to your colleagues. This was designed by me and is for your

personal (one user)use. You may

not share it or claim it as your own. You may not redistribute it.

If colleagues are interested in it, please send them the link to my store:

https://www.teacherspayteachers.com/Store/Next-Gen-Sci-Guy

• You are not permitted to use any part of this work to

create products for sharing or selling.

• You are permitted to share the cover image of the packet

on your website when referring to it in a post, as long as

you link back to my store.

All rights reserved by author.

Report this resource to TPT
Reported resources will be reviewed by our team. Report this resource to let us know if this resource violates TPT's content guidelines.

Reviews

4.8
Rated 4.76 out of 5, based on 17 reviews
17
ratings
5
14
4
2
3
1
2
0
1
0
Mostly used with 9th and 10th grades
Reviews
1
1
6
9
3
5
7th
8th
9th
10th
11th
12th
All verified TPT purchases
Very involved
Rated 4 out of 5
April 14, 2026
This is a great tool if you have the time to do it and do it well. I have 45 minutes, and short calendar, will try with AP Bio next year
Kelly O.
65 reviews • Texas
Grades taught: 10th
Worth every penny
Rated 5 out of 5
February 9, 2026
This was a great activity I used with freshman bio and as a review for my biotech elective. So engaging!!
Alayna T.
235 reviews • Connecticut
Grades taught: 9th, 10th, 11th, 12th
I love this!
Rated 5 out of 5
January 27, 2026
Met expectations
Great value
Such a great activity to show students protein folding literally. My advanced 9th graders did well with this activity. I did have them skip some of the review of things they've been taught already so that we could get to the origami during class time. I did notice one minor issue that the printout for the mutated hemoglobin has heme groups in different places compared to the folding tutorial video. (Update: On further thought, the printout does makes sense, since sickled hemoglobin can still carry oxygen, just transports it inefficiently because of sickle fibers forming.)
Grace K.
1 review
Grades taught: 9th, 10th
fun activity during class
Rated 5 out of 5
December 8, 2025
The origami is what my students liked most and will used again next year.
Ana J.
695 reviews • California
Grades taught: 9th, 10th, 11th, 12th
Rated 5 out of 5
February 7, 2025
I didn't use this resource, but wanted to leave positive feedback. It really is a great resource for protein shape/ mutations. After I bought it, it was just too advanced for my 7th graders. It's awesome for high school curriculum though!
Donna B.
241 reviews
Rated 5 out of 5
September 3, 2024
Great extension for Bio 1 students. Used as a refresher in Bio 2 class. All the kids had a blast! Plan on using again for Bio 1 EOC review activity.
Amanda G.
284 reviews
Grades taught: 12th
Rated 3 out of 5
April 11, 2023
My students struggled a quite a bit with the activity, I changed it up a bit before, and had to do more editing while teaching the lesson. Cool activity! Just didn't work as well as I had hoped for my students!
Marissa T.
48 reviews
Grades taught: 10th
Next Gen Sci Guy
Response from
Next Gen Sci Guy
(TPT Seller)
Apr 13, 2023
I’m sorry to hear that. My students really enjoy this, and most have fun with the challenge of making origami proteins.
Rated 5 out of 5
May 25, 2022
Good stuff, well done!
Michael R.
248 reviews
Grades taught: 12th

Questions & Answers

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