This TED-Ed companion resource explores the surprising medical importance of horseshoe crab blood and the ethical challenges surrounding its use. Students learn how amebocytes detect bacterial endotoxins, why the LAL test is essential for medical safety, and how human reliance on horseshoe crab blood affects the species and its ecosystem. The resource includes 20 discussion questions, a structured debate with clearly labeled positions, and two essay-writing options: a fully expanded, evidenc