Looking for a fun way to introduce the topic of cell communication to your Biology or AP Biology class? In this lesson, students explore the anti-inflammatory properties of pumpkin spice by modeling histamine- and cytokine-blocking actions of bioactive molecules including cinnamaldehyde and gingerol. This lesson includes: 1) Step-by-step lesson plan 2) Editable Google slides presentation on cell communication and inflammation 3) Reproducible student worksheet 4) Stress-Less Pumpkin Spice Scon