DNA profiling, STR analysis, CODIS database lesson, forensic biology emergency sub plan. Includes general & inclusive versions, guided reading, match simulation, and no-prep 45–50 minute activities. Introduce your students to how DNA evidence actually works — beyond TV crime shows. This rigorous forensic biology lesson focuses on STR analysis, PCR, and CODIS, helping students understand what a DNA “match” really means — and what it does NOT mean. Perfect for: • 45–50 minute class periods • B