This Psychology worksheet supports students in mastering the difference between agonists and antagonists by moving beyond memorized definitions to applied examples. Students work through short practice items, real-world drug scenarios (including Parkinson’s medications, antipsychotics, nicotine, and naloxone), and a structured compare–contrast organizer to determine whether a substance mimics or increases a neurotransmitter’s effect (agonist) or blocks and diminishes it (antagonist). The workshe