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DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!
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What others say

"My forensics class was coming to an end and I wanted to teach them about DNA Fingerprinting and profiling before our term ended. This was the perfect resource. Thank you"
star
Christina S.
"This was a fun way to learn how DNA fingerprinting occurs. My students had fun discovering "who dun it" and stayed engaged throughout. "
star
Miranda M.

Description

Model DNA Fingerprinting/DNA Profiling with this digital resource! Your students will walk through the Three Steps of making a DNA Fingerprint. Then they use what they learned to create four DNA Fingerprints and solve a murder case!

All learning and instructions for the activity are included on the slides for them - truly no prep! Students can complete the activity on their own - or work in pairs.

Resource includes:

  • How are DNA Fingerprints Made? Fourteen interactive Google Slides that teach students the process, tools needed, and reason behind each step of DNA Fingerprinting. Students model the process of DNA Fingerprinting as they learn. (See details below)
  • DNA Fingerprinting Notes: This graphic organizer provides students a place to record the steps of DNA Fingerprinting. It can be printed and completed on paper, or digitally on Google Slides
  • DNA Fingerprinting Review: A self grading Google Form with 12 multiple choice questions, a perfect informal assessment to see what your students have learned.
  • Complete Answer Key 
  • Teacher Guide for how to use the activity

All parts of this resource are editable!

Details - What your students will learn:

  • First, students are introduced to the crime - the murder of Harry Monroe. Who did it? Blood spatter evidence suggests that the attacker was also injured. A blood sample is taken to make a DNA Fingerprint from.
  • Students meet the three suspects, their possible motives and stated alibis. DNA samples are taken from them to compare with the blood at the crime scene.
  • Three steps of DNA Fingerprinting:
    • Cut the DNA with a Restriction Enzyme - students drag and drop ‘scissors’ that represent the restriction enzyme to cut samples of DNA into different sized pieces
    • Copy the DNA Pieces with the PCR Machine - students make copies of each piece of DNA, and learn why this step is so important
    • Separate DNA Pieces by Size with a Gel Electrophoresis Machine - Simple illustrations ‘zoom in’ on DNA in the gel, explain why the DNA moves through the gel, and why smaller pieces move quickly to the bottom while larger pieces get stuck near the top. 
  • Finally, students drag fragments of DNA through a ‘gel’, making four DNA Fingerprints (that of the crime scene blood and of the three suspects). The DNA FIngerprint of only one suspect matches the blood! 
  • Along the way students answer questions about what they learn by typing directly onto the Google Slides

I love seeing my students light up when they solve the case!

Looking for more Forensic DNA Evidence resources? Here is the full Unit! 

Here are some other fun Forensic Science lessons and activities!

**Stay Curious!**

Report this resource to TPT
Reported resources will be reviewed by our team. Report this resource to let us know if this resource violates TPT's content guidelines.

DNA Fingerprinting/DNA Profiling Activity: Learn & Model - NO PREP!

Science of Curiosity
2.5k Followers
$3.50

Highlights

Digital downloads
Grades icon
Grades
9th - 12th
Standards icon
Standards
Answer Key
Included

What others say

"My forensics class was coming to an end and I wanted to teach them about DNA Fingerprinting and profiling before our term ended. This was the perfect resource. Thank you"
star
Christina S.
"This was a fun way to learn how DNA fingerprinting occurs. My students had fun discovering "who dun it" and stayed engaged throughout. "
star
Miranda M.

Save even more with bundles

High School Forensics Curriculum Bundle for one semester (90+ days)! Includes seven full forensic units, three projects, hands on labs and activities, review games, review questions, assessments for each unit, and a final exam.  Teaching Forensic Science with this Bundle is STRESS FREE! Most of thes
Price $146.60Original Price $183.25Save $36.65
52
Everything you need to teach DNA Fingerprinting as Forensic Evidence! NO PREP - Digital and Paper options for distance learning or in class! DNA Evidence teaching slides, notes sheets, DNA Fingerprinting Digital Model activity, and Project!Teaching Slides: Forty one Google Slides! Topics covered:Wha
Price $13.80Original Price $17.25Save $3.45
5
High School Forensics Curriculum Bundle for the WHOLE YEAR! Includes eleven full forensic units, six projects, hands on labs and activities, review games, review questions and assessments. NGSS Aligned! Teaching Forensic Science with this Bundle is STRESS FREE! Most of these resources are NO PREP a
Price $260.20Original Price $325.25Save $65.05
87

Description

Model DNA Fingerprinting/DNA Profiling with this digital resource! Your students will walk through the Three Steps of making a DNA Fingerprint. Then they use what they learned to create four DNA Fingerprints and solve a murder case!

All learning and instructions for the activity are included on the slides for them - truly no prep! Students can complete the activity on their own - or work in pairs.

Resource includes:

  • How are DNA Fingerprints Made? Fourteen interactive Google Slides that teach students the process, tools needed, and reason behind each step of DNA Fingerprinting. Students model the process of DNA Fingerprinting as they learn. (See details below)
  • DNA Fingerprinting Notes: This graphic organizer provides students a place to record the steps of DNA Fingerprinting. It can be printed and completed on paper, or digitally on Google Slides
  • DNA Fingerprinting Review: A self grading Google Form with 12 multiple choice questions, a perfect informal assessment to see what your students have learned.
  • Complete Answer Key 
  • Teacher Guide for how to use the activity

All parts of this resource are editable!

Details - What your students will learn:

  • First, students are introduced to the crime - the murder of Harry Monroe. Who did it? Blood spatter evidence suggests that the attacker was also injured. A blood sample is taken to make a DNA Fingerprint from.
  • Students meet the three suspects, their possible motives and stated alibis. DNA samples are taken from them to compare with the blood at the crime scene.
  • Three steps of DNA Fingerprinting:
    • Cut the DNA with a Restriction Enzyme - students drag and drop ‘scissors’ that represent the restriction enzyme to cut samples of DNA into different sized pieces
    • Copy the DNA Pieces with the PCR Machine - students make copies of each piece of DNA, and learn why this step is so important
    • Separate DNA Pieces by Size with a Gel Electrophoresis Machine - Simple illustrations ‘zoom in’ on DNA in the gel, explain why the DNA moves through the gel, and why smaller pieces move quickly to the bottom while larger pieces get stuck near the top. 
  • Finally, students drag fragments of DNA through a ‘gel’, making four DNA Fingerprints (that of the crime scene blood and of the three suspects). The DNA FIngerprint of only one suspect matches the blood! 
  • Along the way students answer questions about what they learn by typing directly onto the Google Slides

I love seeing my students light up when they solve the case!

Looking for more Forensic DNA Evidence resources? Here is the full Unit! 

Here are some other fun Forensic Science lessons and activities!

**Stay Curious!**

Report this resource to TPT
Reported resources will be reviewed by our team. Report this resource to let us know if this resource violates TPT's content guidelines.

Reviews

4.7
Rated 4.68 out of 5, based on 38 reviews
38
ratings
5
29
4
8
3
0
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0
1
1
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All verified TPT purchases
Exactly what I needed
Rated 5 out of 5
March 7, 2026
Met expectations
Great value
Standards-aligned
My forensics class was coming to an end and I wanted to teach them about DNA Fingerprinting and profiling before our term ended. This was the perfect resource. Thank you
Christina S.
239 reviews • California
Grades taught: 7th, 8th
Engaging Activity
Rated 5 out of 5
February 3, 2026
This was a fun way to learn how DNA fingerprinting occurs. My students had fun discovering "who dun it" and stayed engaged throughout.
Miranda M.
301 reviews • Texas
Grades taught: 6th, 7th, 8th, 9th
Student populations: Emerging bilinguals
So Fun and Educational.
Rated 5 out of 5
October 28, 2025
This was a really fun way to learn. I added this resource to my genetics pack.
Mary W.
42 reviews • California
Grades taught: 9th, 10th, 11th, 12th
Great DNA Fingerprinting resource
Rated 5 out of 5
October 6, 2025
Met expectations
Great value
Standards-aligned
I used this as a sub plan lesson and it went great!
Brianna G.
46 reviews • Idaho
Grades taught: 11th, 12th
Great activity
Rated 5 out of 5
August 3, 2025
Met expectations
Great value
Standards-aligned
Great to use for in-person learning, virtual students, and as a make-up assessment for students who had been absent.
Amanda Davis
(TPT Seller)
50 reviews
Grades taught: 11th, 12th
Student populations: Autism, Emerging bilinguals, Learning difficulties
Great Activity for Student Led Learning
Rated 5 out of 5
July 29, 2025
Met expectations
Great value
Standards-aligned
This is a great way to introduce or reenforce lessons. I love that it is no prep...making life easier.
Stephanie Davidson
(TPT Seller)
657 reviews
Grades taught: 12th
Rated 4 out of 5
February 14, 2025
This activity was great practice for my students after they learned the basics of DNA fingerprinting
Amber C.
326 reviews
Grades taught: 10th, 11th
Rated 5 out of 5
January 27, 2025
Great activity that aligned perfectly with what we are studying in class!
Kelly C.
587 reviews
Grades taught: 10th, 11th

Questions & Answers

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Standards

to see state-specific standards (only available in the US).
NGSSHS-LS1-1
Construct an explanation based on evidence for how the structure of DNA determines the structure of proteins, which carry out the essential functions of life through systems of specialized cells. Assessment does not include identification of specific cell or tissue types, whole body systems, specific protein structures and functions, or the biochemistry of protein synthesis.
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